Professor Caroline Dean
Caroline Dean has been a project leader at the John Innes Centre Norwich since 1988. Her work on seasonal timing mechanisms in plants has led into a detailed mechanistic analysis of the regulation of one Arabidopsis locus, encoding the floral repressor FLC. FLC transcription is quantitatively modulated by an antisense-mediated chromatin mechanism that coordinately influences transcription initiation and elongation. The gene is also epigenetically silenced through a cold-induced, cis-based, Polycomb switching mechanism. FLC has thereforeturned out to be an excellent system to dissect conserved mechanisms by which non-coding transcription and chromatin mechanisms regulate gene expression.
Caroline was elected to EMBO in 1999, Fellow of the Royal Society in 2004, and US National and German Leopoldina Academy in 2008. She was awarded an OBE in 2004 and then appointed Dame Commander in 2016. She was a 2018 L’Oreal Woman in Science Laureate.